Generally I recommend that you leave "Sell based on strategy" disabled, but it can be enabled depending on your preference. If you enable it, there will be some sales with lower profits and losses, but you won't hold onto negative/unprofitable positions long and free up funds to make additional profitable trades. If you leave it off, you only sell when you get the full profit (as configured in the settings), but will hold onto negative positions longer until they become profitable on their own or with the help of Dollar Cost Averaging.

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